Aptamil Pepti Syneo

Our synbiotic EHF*. Uniquely combined^†, clinically proven^1-4.

Aptamil Pepti Syneo is a whey-based extensively hydrolysed formula (EHF) for the dietary management of Cow's Milk Allergy (CMA). It is a nutritionally complete hypoallergenic formula, suitable as a sole source of nutrition from birth.

Aptamil Pepti Syneo is the only^†EHF to contain a synbiotic blend of both prebiotics and probiotics*¹¹.

With Aptamil Pepti Syneo, the benefits stack up

Rebalances the gut microbiota²

SYNBAD study:

After 12 weeks of taking Aptamil Pepti Syneo, the gut microbiota of infants with AD is brought closer to that of healthy breastfed infants².

Significant difference in gut microbiota composition at week 12, Aptamil Pepti Syneo vs a non-synbiotic EHF:²

Improves allergic symptom management compared with non-synbiotic EHFs^2‡,3#

Aptamil Pepti Syneo is shown to support reductions in:

abdominal discomfort^3# and wind^3#

rhinitis severity^3# and itchy eyes^3#

constipation^2,3#and dry stools²

atopic dermatitis severity^2‡,3#

Improvements in allergic symptoms may help ease the burden of CMA on parents and caregivers^3,16

An increase in parental QoL scores have been observed in just 4 weeks following introduction of Aptamil Pepti Syneo^3#

Supports long-term effects^3#,4§

Compared to a non-synbiotic EHF in a 1-year follow-up of the SYNBAD study, those in the Aptamil Pepti Syneo group showed significantly less:^4§

Frequent wheezing

Wheezing and/or noisy breathing (apart from colds)

Asthma medication use

UK CMA study:

Aptamil Pepti Syneo has also been shown to significantly reduce hospital visits and hospital medication prescriptions in infants with CMA in the 6 months after initiation^3#

Part of the UK’s most palatable EHF range^5-7

Palatability is an important consideration in EHF choice^5,12

95% of surveyed HCPs ranked Aptamil Pepti Syneo or Aptamil Pepti 1 as the most liked EHFs⁶

More on Aptamil Pepti Syneo

Prebiotics and probiotics: what are they?

Learn about our synbiotic blend

What is the difference between Aptamil Pepti Syneo and Aptamil Pepti 1?

Aptamil Pepti 1 is an extensively hydrolysed formula also suitable for the dietary management of Cow’s Milk Allergy from birth.

Aptamil Pepti 1 contains prebiotic GOS/FOS (galacto-oligosaccharides and fructo-oligosaccharides) and Aptamil Pepti Syneo includes the synbiotic blend of both prebiotics (galacto-oligosaccharides and fructo-oligosaccharides) and probiotics (Bifidobacterium breve M-16V).

Order your free sample

Order your sample of Aptamil Pepti Syneo here, to be sent to you or directly to your patient

Order now

*Product can be provided to patients upon the request of a Healthcare Professional. They are intended for the purpose of professional evaluation only.

IMPORTANT NOTICE: Breastfeeding is best. Aptamil Pepti 1 & 2 and Pepti Syneo are foods for special medical purposes for the dietary management of cows’ milk allergy. They should only be used under medical supervision, after full consideration of the feeding options available including breastfeeding. Aptamil Pepti 1 and Pepti Syneo are suitable for use as the sole source of nutrition for infants from birth and/or as part of a balanced diet from 6-12 months. Aptamil Pepti 2 is suitable for use for infants from 6 months as part of a balanced diet. Refer to label for details.

*SYNEO synbiotic blend: Bifidobacterium breve M-16V (probiotic) & short and long-chain galacto- and fructo-oligosaccharides (prebiotic).

†The only synbiotic blend within an EHF in the UK. Market comparison of UK EHF data cards, October 2023.

‡12-week RCT². Infants with Atopic Dermatitis, Aptamil Pepti Syneo vs non-synbiotic EHF. Subgroup of n=50 infants with IgE associated AD, difference in SCORAD score Aptamil Pepti Syneo vs non-synbiotic EHE, -4.6, 95% CI, p=0.04.

#Single arm UK non-IgE mediated CMA study³, baseline non-synbiotic formula (n=27 out of n=29 well established on a non-synbiotic EHF) vs Aptamil Pepti Syneo, 4 week intervention. Sig reduction in GI symptoms (abdominal pain, wind, & constipation p=<0.05), reduction in severity of rhinitis (p<0.05) and itchy eyes (p<0.05). Significant reduction in PO-SCORAD in subgroup of n=6 infants with more severe AD at baseline, p=0.03. Mean number of overall hospital visits and hospital medication prescriptions significantly reduced (p<0.05) in the 6 months after Aptamil Pepti Syneo initiation compared with 6 months prior. n=13 included in the follow-up analysis.

§1 year follow up⁴ from 12 week RCT². Significantly lower prevalence of asthma like symptoms and significantly fewer new users of asthma medication in the Aptamil Pepti Syneo group vs non-synbiotic EHF.

**Contains more of the gut microbiota modulating factors of breastmilk than any other EHF (prebiotic oligosaccharides, probiotic bacteria and lactose). Aptamil Pepti Syneo compared to all other UK EHFs.

AD: atopic dermatitis; CMA: Cow’s Milk Allergy; EHF: Extensively Hydrolysed Formula; FOS: fructo-oligosaccharide; GI: gastrointestinal; GOS: galacto-oligosaccharide; lc: long-chain; OS: oligosaccharide; PO-SCORAD: Patient-Orientated SCORAD; QoL: quality of life; RCT: Randomised Controlled Trial; sc: short-chain; SCORAD: SCOring of AD; SYNBAD: Synbiotics in Atopic Dermatitis

1. Abrahamse-Berkeveld, et al. J Nutr Sci. 2016;5:e42.

2. van der Aa, et al. Clin Exp Allergy. 2010;40(5):795-804.

3. Hubbard, et al. Immun Inflamm Dis. 2022;10(6):e636.

4. van der Aa, et al. Allergy. 2011;66(2):170-7.

5. Maslin, et al. Pediatr Allergy Immunol. 2018;29(8):857-62.

6. Data on file, updated independent taste panel report, Campden BRI, October 2020. n=102 HCPs, Campden BRI blind home usage taste testing, n=102 Dietitians and General Practitioners. Aptamil Pepti 1 & Pepti Syneo vs all UK EHFs suitable from birth.

7. Sorensen, et al. Poster Presentation. European Academy of Allergy and Clinical Immunology. 2022.

8. Market comparison of UK EHF prices per 400g tin, NHSBA dm+d browser, October 2023. Aptamil Pepti 1, 2 & Syneo vs Alimentum, Nutramigen LGG 1, 2 & 3 and SMA Althera.

9. Scholtens, et al. Annu Rev Food Sci Technol. 2012;3:213.

10. Andreas, et al. Early Human Dev. 2015;91(11):629–35.

11. Market comparison of UK EHF data cards, October 2023.

12. Luyt, et al. Clin Exp Allergy: J Br Soc Allergy Clin Immunol. 2014;44(5):642-72.

13. Mead Johnson Nutrition. Nutramigen LGG 1 Data Card. Available at https://www. hcp.nutramigen.co.uk/s/nutramigen-1-with-lgg (accessed October 2023).

14. Abbott. Alimentum Data Card. Available at https:// nutrition.abbott/uk/product/alimentum (accessed October 2023).

15. Nestle Health Science. Althera data card. Available at https://www. nestlehealthscience.co.uk/brands/althera-and-alfamino/althera-hcp (accessed October 2023).

16. Sorensen, et al. Immun Inflamm Dis. 2022;10(3):e572.

Accurate at time of publication: October 2023

You may also be interested in

Diagnosis and management

Learn about the appropriate assessment and diagnosis of CMA, according to relevant guidelines, and when to use an amino acid formula

What are synbiotics?

Learn about the role synbiotics can take in the management of CMA in formula-fed infants.

Eliminating the allergen, modulating the microbiota

Review the clinical evidence supporting synbiotics in the dietary management of CMA

• Our free Sampling Service to order product samples and have them sent to your patients' homes.
• A range of CPD accredited e-learning programmes.
• Order free paper copies of our support tools for yourself or to use with your patients.
• Sign up to receiving marketing communications and be the first to know about our free educational events & webinars, the latest scientific research and product updates.

Help us provide information most relevant to you

Please ensure your role and areas of interest are up to date.

Update profile

Also on this website

About Nutricia

Follow us on LinkedIn

Follow us on Twitter

^{Nutricia Limited is a company registered in England and Wales with company number 00275552. VAT Number GB436975115}

Aptamil Pepti Syneo

Our synbiotic EHF*. Uniquely combined^†, clinically proven^1-4.

With Aptamil Pepti Syneo, the benefits stack up

Rebalances the gut microbiota²

Improves allergic symptom management compared with non-synbiotic EHFs^2‡,3#

Supports long-term effects^3#,4§

Part of the UK’s most palatable EHF range^5-7

More on Aptamil Pepti Syneo

Prebiotics and probiotics: what are they?

What is the difference between Aptamil Pepti Syneo and Aptamil Pepti 1?

Order your free sample

*Product can be provided to patients upon the request of a Healthcare Professional. They are intended for the purpose of professional evaluation only.

You may also be interested in

Diagnosis and management

What are synbiotics?

Eliminating the allergen, modulating the microbiota

Nutricia offers access to a wide range of support services and resources including:

Help us provide information most relevant to you

Login

Aptamil Pepti Syneo

Our synbiotic EHF*. Uniquely combined†, clinically proven1-4.

With Aptamil Pepti Syneo, the benefits stack up

Rebalances the gut microbiota2

Improves allergic symptom management compared with non-synbiotic EHFs2‡,3#

Supports long-term effects3#,4§

Part of the UK’s most palatable EHF range5-7

More on Aptamil Pepti Syneo

Prebiotics and probiotics: what are they?

What is the difference between Aptamil Pepti Syneo and Aptamil Pepti 1?

Order your free sample

*Product can be provided to patients upon the request of a Healthcare Professional. They are intended for the purpose of professional evaluation only.

References

You may also be interested in

Diagnosis and management

What are synbiotics?

Eliminating the allergen, modulating the microbiota

Nutricia offers access to a wide range of support services and resources including:

Help us provide information most relevant to you

Login

Please choose

Our synbiotic EHF*. Uniquely combined^†, clinically proven^1-4.

Rebalances the gut microbiota²

Improves allergic symptom management compared with non-synbiotic EHFs^2‡,3#

Supports long-term effects^3#,4§

Part of the UK’s most palatable EHF range^5-7