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Nutricia Ketogenic Product Range

Nutricia offers products and services to simplify and enhance ketogenic dietary therapy. Our globally available products have an over 20-year track record, backed by clinical evidence1 and trusted by healthcare professionals and patients worldwide. The KetoCal® range is suitable for various ketogenic diets, including Classical, MCT, Modified, and Low Glycaemic Index. Ready-made ratios make adhering to a ketogenic diet straightforward and convenient.

KetoCal®’s effectiveness in seizure reduction is backed by over 20 years of research and more than 35 scientific studies in over 1,400 patients worldwide.1

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Nutricia was the first company to co-create the first ketogenic diet formula in 1998 with experts from John Hopkins Hospital in Baltimore USA1. Today, the Nutricia Ketogenic Range provides everything dietitians need to support initiation and adherence to ketogenic diet therapy (KDT):

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  • Nutritional formula from infancy to adulthood
  • Good tasting products2
  • With a patented fibre blend (all KetoCal® products except KetoCal® 3:1 powder)
  • A Ketogenic range backed by over 20 years of research and over 35 scientific publications1

Nutricia Ketogenics Product Selection Guide

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All KetoCal® products have lower saturated fat than typical high fat foods, like double cream*. KetoCal® 4:1 LQ contains only 13% of energy from saturated fats and KetoCal® 2.5:1 LQ contains only 35% of energy from saturated fats. By comparison, fatty foods like double cream contain approx. 60% of energy from saturated fats.

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* https://www.gov.uk/government/publications/composition-of-foods-integrated-dataset-cofid. Accessed June 2024.

KetoCal® 4:1 LQ is a 4:1 ratio liquid with an advanced fat profile which provides a convenient way of administering Ketogenic Diet Therapy: as a drink, in meals or as a tube feed. It is suitable as the sole source of nutrition for 1 years+ or for supplementary feeding. Great as a bedtime drink or for lunch boxes.

Liquid Ketogenic Diet Therapy with KetoCal® achieves seizure reduction fast. 3

Initiation on a liquid KetoCal® diet is proven to be effective3 :  

  • Stable ketosis in 7 days
  • Greater than 50% reduction in seizures in 14 days
  • Rapid assessment of efficacy of the Ketogenic Diet Therapy within 6 weeks

Furthermore, a liquid KetoCal® diet is proven to be an easy and practical method of initiating Ketogenic Diet Therapy:

  • With high adherence, especially in out-patient setting3
  • Providing complete and balanced nutrition

 

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Product features:

  • Available in 200ml cartons
  • Two flavours: unflavoured and vanilla
  • Quick and easy: ready to drink liquid
  • Can be used in all forms of Ketogenic Diet Therapy: Classical, MCT diets or Modified Ketogenic Diet
  • Contains a patented, multi-fibre blend (MF6TM) to help meet daily fibre needs and support gut health as fibre intake is reduced in Ketogenic Diet Therapy4,5
  • Advanced fat profile: reduces the intake of saturated fat for long-term health benefits. 6-8

KetoCal® reduces the need to consume large amounts of dietary fat by providing a tasty2 way to increase fat intake.

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KetoCal® 4:1 Powder is a versatile 4:1 ratio powder with an advanced fat profile which can be made up as a drink, as a tube feed or used as an ingredient in many ketogenic recipes both sweet and savoury. It’s ideal for use as a flour substitute.

It is suitable as the sole source of nutrition for children aged 1-10 years, or for supplementary feeding over the age of 10 years.

KetoCal® May Improve Seizure Control and Tolerability in Ketogenic Diets for Young Children with Refractory Epilepsy9

A randomised control trial conducted in 2019 showed that the addition of a formula-based ketogenic powder like KetoCal® to the classical ketogenic diet may improve seizure control and diet tolerability in young children with refractory epilepsy.

Key outcomes in patients following a Classical Ketogenic Diet (CKD) with KetoCal® Powder:

  • KetoCal® group experienced a significant 50% or greater reduction in seizure frequency versus classic ketogenic diet alone group (p-value<0.05)
  • KetoCal® group response was significantly better at 3 & 6 months in myoclonic seizures and infantile spasms  
  • EEG normalisation significantly more common in KetoCal® group after 6 months (p-value <0.05)
  • Significant developmental improvements in KetoCal® group, with fewer children experiencing cognitive delays after 6 months
  • KetoCal® group adhered to diet for a longer period, suggesting better tolerability ​(p-value<0.05)​
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Product features:

  • Available in 300g tins
  • Two flavours: unflavoured, vanilla
  • Can be used in all forms of Ketogenic Diet Therapy: Classical, MCT diets or Modified Ketogenic Diet
  • Contains a patented, multi-fibre blend (MF6TM) to help meet daily fibre needs and support gut health as fibre intake is reduced in Ketogenic Diet Therapy4,5
  • Advanced fat profile: reduces the intake of saturated fat for long-term health benefits and includes EFAs, DHA and AA and LCPs. 6-8

KetoCal® 3:1 Powder is a nutritionally complete ketogenic formula in a 3:1 ratio appropriate to use from birth to 1 year and as a supplementary feed for infants and children over the age of 3 years. It can be made up as a drink or used as an ingredient, as a flour substitute, in many ketogenic recipes both sweet and savoury.

Product features:

  • The ONLY 3:1 Ketogenic formula available for infants
  • Suitable as the sole source of nutrition until 3 years and as a supplementary feed for infants and children aged over 3 years.
  • Can be used in all forms of Ketogenic Diet Therapy: Classical, MCT diets or Modified Ketogenic Diets
  • The balanced fatty acid profile may help keep lipid profile within the normal range

KetoCal® 2.5:1 LQ is a 2.5:1 ratio ready to drink liquid suitable as the sole source of nutrition or for supplementary feeding. KetoCal® 2.5:1 LQ was developed to meet the protein needs of upper age patients and is suitable for complete nutritional support from 8 years+.

Product features:

  • Available in 200ml cartons
  • Great mild creamy vanilla taste
  • 9g protein per 200ml carton
  • Added MCT to aid efficacy
  • Convenient and easy to use ready to drink liquid
  • Can be used in all forms of Ketogenic Diet Therapy: Classical, MCT diets or Modified Ketogenic Diet
  • Contains unique MF6™ Multifibre blend
  • Balanced fatty acid profile
  • The balanced fatty acid profile may help keep lipid profile within the normal range

Liquigen is a 50% MCT fat emulsion that can be used as part of a modular feed. Liquigen can be used in a range of ketogenic diets and is ideal as a supplement to boost ketosis.

Product features:

  • Suitable for all ages
  • 50% MCT fat emulsion
  • 250ml resealable plastic bottles
  • Can be easily flavoured
  • Liquigen can be mixed with liquids, used as a milk substitute or used as a cooking ingredient
  • Liquigen should be introduced slowly into the diet as rapid absorption of large intakes may cause vomiting or diarrhoea

MCT oil is a 100% MCT fat emulsion that can be used in a range of ketogenic diets. It is ideal as a supplement to boost ketosis.

Product features:

  • Suitable for all ages
  • 500ml resealable plastic bottles
  • Suitable for cooking, bringing more variety at mealtimes
  • MCT Oil can be mixed with liquids or used as a cooking ingredient
  • MCT Oil should be introduced slowly into the diet as rapid absorption of large intakes may cause vomiting or diarrhoea

Nutricia Ketogenic Products can be easily incorporated into patients’ diet

Watch this video by Chef Derek, Nutricia’s Ketogenic Specialist Chef, explaining how our ketogenic products can be used and how they can be incorporated into ketogenic meals, bringing more variety to your diet.

What patients say about KetoCal®

“We travel often, and KetoCal® 4:1 LQ is easy to pack and take anywhere! Coco has been on the ketogenic diet for 6 years now, and KetoCal® has been an invaluable aide every step of the way.”
(Shelly & John about their daughter Colleen, 8 years old, USA)

 

“My dietitian helped me obtain the KetoCal® 4:1 LQ formula to reduce the stress of meal planning since I was attending work, school, and the swim team. For the first time since my seizures began, I went two months seizure-free.”
(Hailey, a patient’s story from the USA)

 

“We started out slowly by using her formula mixed with KetoCal® 4:1 powder. Then we kept adding more KetoCal® while decreasing the other formula until she was getting all KetoCal®… I started noticing a decrease in seizures.”       
(Leah, a patient’s story from the USA)

  1. Data on file, 2023
  2. Non blinded tasting survey with 107 dietitians done in 2019. Data on file.
  3. Weijenberg A, van Rijn M, Callenbach PMC, et al. Ketogenic diet in refractory childhood epilepsy: Starting with a liquid formulation in an outpatient setting. Child Neurol Open. 2018;5:2329048x18779497.
  4. Bergqvist AG. Long-term monitoring of the ketogenic diet: Do’s and Don’ts. Epilepsy Res. 2012;100(3):261–6
  5. Elia M., Engfer M.B. et al. (2008) ‘Systematic Review and Meta-Analysis: the Clinical and Physiological Effects of Fibre-Containing Enteral Formulae’ Alimentary Pharmacology Therapeutics, 27(2), pp. 120–145.
  6. Fuehrlein, B.S., Rutenberg, M.S. et al. (2004) ‘Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets’, Journal of Clinical Endocrinology Metabolism, 89(4), pp. 1641–1645.
  7. Dahlin M. Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy. Epilepsy Res. 2007;73:199–207.
  8. Kwiterovich P.O., Vining EPG, Pyzik P. et al. Effect of a High-Fat Ketogenic Diet on Plasma Levels of Lipids, Lipoproteins, and Apolipoproteins in Children. Journal of American.
  9. Karimzadeh P et al. 2019. Effects of a Formula-Based Ketogenic Diet on Refractory Epilepsy in 1 to 3 Year-Old Patients under Classic Ketogenic Diet. Iran J Child Neurol. Autumn 2019 Vol.13 No. 4
  10. MIMS data accessed July 2024

KDT – Ketogenic Diet Therapy

CKD – Classical Ketogenic Diet

MCT – Medium-Chain Triglycerides

EEG – Electroencephalogram

EFAs - Essential Fatty Acids

DHA – Docosahexaenoic acid

AA – Amino acid

LCPs - Long chain polyunsaturated fatty acids

Disclaimer

This information is intended for Healthcare Professionals. All products shown are Foods for Special Medical Purposes for the dietary management of drug resistant epilepsy, or other conditions where the use of the ketogenic diet is indicated, and must be used under medical supervision.

  • Nutricia Limited is a company registered in England and Wales with company number 00275552. VAT Number GB436975115
  • © 2024 Nutricia. All rights reserved.
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