KetoConference2024 - Maintenance of response to ketogenic diet therapy for drug-resistant epilepsy post diet discontinuation

Dr Natasha Schoeler discusses a multi-centre case note review aimed at determining the proportion of individuals who maintain response post Ketogenic Diet Therapy in this talk from KetoConference 2024 titled 'Maintenance of response to ketogenic diet therapy for drug-resistant epilepsy post diet discontinuation: a multi-centre case note review'.

Maintenance of response to ketogenic diet therapy for drug-resistant epilepsy post diet discontinuation: a multi-centre case note review - Dr. Natasha E Schoeler

This presentation, led by Natasha Schoeler and colleagues from the Ketogenic Dietitians Research Network, explores the long-term effectiveness of ketogenic diet therapy (KDT) for drug-resistant epilepsy after discontinuation. Drawing on data from 97 individuals across 9 centres, this review aims to identify the proportion of patients who maintain seizure reduction post-KDT and the factors that influence long-term response.

Key topics include:

  • Long-term response: Analysis of patients who maintained ≥50% seizure reduction after stopping KDT and the likelihood of maintaining response without additional anti-seizure treatments.
  • Predictive factors: How seizure freedom during diet therapy impacts the probability of maintaining seizure control post-diet, and the risks of seizure recurrence for those who did not achieve seizure freedom.
  • Clinical implications: Practical considerations for guiding patients and families on the long-term outcomes of KDT and realistic cost assessments for KDT services.

This multi-centre case note review provides valuable insights for clinicians in supporting patient and family expectations regarding long-term seizure management with KDT.

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