Preterm infants have increased nutrient requirements to achieve the growth velocity of a child growing in its mother’s womb^4,5. These requirements are much higher than those of a term born peer^4-6. Medical associations such as the European Society for Gastroenterology, Hepatology, and Nutrition (ESPGHAN)⁶ and American Academy of Pediatrics (AAP)⁷ as well as neonatal experts⁸ address these requirements by giving specific recommendations for premature infants born weighing less than 1000g, less than 1500g and less than 1800g. All these associations acknowledge that protein is a key nutrient in avoiding growth failure as long as enough energy is provided^6-8.

In support of optimal growth and development, preterm nutrition should address:

• High nutritional needs and growth velocity versus difficulties of enteral intake
• Instable metabolsim due to immature gastrointestinal development
• Immature / compromised immune system
• Delayed colonisation and compromised microbiota development
• Sensitive phase of brain development

In line with the World Health Organisation (WHO) we believe that human milk is the best nutrition for preterm infants⁹. Breastfeeding and human milk (HM) are the preferred feeding mode and nutrition for every infant^10-13.

The composition of HM is highly variable and tailored to the personal nutritional needs of an infant^14-16. For preterm infants on parenteral feeds, trophic feeding with HM soon after birth is recommended to prepare the intestine for enteral feeding^3,11,12.

Beyond the benefits of breastfeeding known for term infants¹⁷, providing HM to premature infants:

• offers immune protection against infection^3,11,12
  
• reduces the risk of necrotising enterocolitis (NEC)^3,11,12
• prepares the gut for enteral feeding^3,11,12
• supports healthy gut development^3,11,12
• provides enzymes for fat absorption¹²
• is associated with improved neurocognitive development^3,11,12
• is tolerated well^3,11,12, and personalised to the mother-infant^15,16

Colostrum, a pre-milk fluid rich in immunoglobulins and immune cells that is produced during the first 24–48 hours postpartum, is especially important for immune protection and gut maturation and should never be discarded¹².

If own mothers milk (OMM) is not available donor human milk (DHM) from milk banks is the next preferred alternative for preterm infant feeding¹³. However, as with OMM, DHM is not nutrient enriched enough to meet the high requirements of extreme and very premature infants and fortification i.e. adding macro- and micronutrients to HM or a multicomponent Human Milk Fortifier (HMF) is required^6,8,18.

HM fortification is associated with improved growth and brain development^{3,6,8,10-13,18}. Infants born weighing less than 1800g are recommended to receive fortified HM enriched in energy, macronutrients, minerals, and vitamins^6,8 to achieve growth rates similar to those of the fetus. However, infants born weighing less than 1000 g and/or those born small-for-gestational age may need an even faster weight gain for recovering growth^19,20 and have therefore even higher protein and energy needs^6,8,18,19.

Avoiding growth failure by meeting the high energy and protein needs is challenging: enteral feeding commonly takes place through naso-gastric tubes because of feeding difficulties⁴. The feed needs to be highly concentrated because of small stomach volumes that limit intake, but also well tolerated^4-6.

An immature gut physiology affects growth. Healthy growth can only be achieved with an intact healthy gut that is capable of digesting and absorbing the provided nutrients, and a metabolism prepared to use nutrients effectively⁴.

The colonic microbiota, compromised in preterm infants because of prophylactic use of antibiotics and pathogens in the hospital environment, play an important role in maintaining a healthy gastrointestinal environment for digestion of nutrients^21,22.

Intestinal microbiota also plays a vital role in the immune system²¹, helping to reduce the risk of infection and necrotising enterocolitis, which compromise survival and/ or growth²².

As such, providing appropriate nutrition to meet the high nutrient and energy requirements and support the colonisation of healthy intestinal microbiota is essential to improve gut and immune health, which provides the platform for adequate growth. Together, these factors create an environment for long term health.

1. Pre-heat oven to 170°C.
2. In a large bowl, cream the butter and sugar together until the mixture is light and fluffy. 
3. Add the golden syrup to the bowl and beat to combine.
4. To the mixture, add the Loprofin Mix, Loprofin Egg Replacer, carrots, spices, Sno-Pro and baking powder mix until you have a soft batter. 
5. Transfer the cake mixture to an 8 inch round greased lined tin and bake for 30–40 minutes or until a skewer inserted into the centre of the cake comes out clean.

To make the low protein cream cheese frosting:

1. Place the low protein cream cheese, butter, icing sugar and vanilla into a bowl and mix until smooth.
   
2. Once the cake has cooled, spread the cream cheese frosting over the top of the cake.

Chef's tips:

• You can add 50g of dried fruit to the basic mix.
• You can also bake this mixture in muffin tins - it will make 12 muffins.

Adequate growth is a major challenge for preterm infants. It is affected by an immature gut and metabolic physiology and as a consequence inadequate intake, digestion, uptake and usage of the nutrients. Moreover suboptimal intestinal microbiota and an immature immune system may play a role in the risk of infection and necrotising enterocolitis, further compromising growth. Together the factors/processes leading to growth failure also impact/ compromise brain development.

Nutricia has over 40 years of breast milk expertise with a dedicated team of around 250 specialist scientists collaborating with hospitals, laboratories and universities worldwide to ensure we’re leaders in this field. At Nutricia, science is at the heart of our nutrition and health commitment to help healthcare professionals support parents during the first 1,000 days. Our research and innovation delivers evidence-based nutritional solutions to support a child’s lifelong health, combining our Early Life Nutrition expertise with years of professional experience to develop a portfolio of products to support the nutritional needs of mums, mums-to-be and their babies.